Open AccessFeatures of the visualization of the liver in children with glycogen storage disease according to data of computed tomography
Author(s) -
А.Н. Сурков,
Л.С. Намазова-Баранова,
О. В. Кустова,
А. С. Потапов,
Anatoliy Anikin,
A. N. Getman,
Vladimir Barskiy,
Г. В. Волынец,
И. Е. Смирнов
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2016-19-5-260-268
Subject(s) - glycogen storage disease , liver parenchyma , parenchyma , medicine , glycogen storage disease type i , computed tomography , abdominal cavity , liver disease , wilson's disease , radiology , pathology , disease , nuclear medicine , gastroenterology , anatomy
Diagnostic value of computed tomography (CT) of the liver imaging in children with glycogen storage disease (GSD) is still poorly understood, in this connection, there were examined 59 patients with essential hypertension (study group) and 27 - with Wilson's disease (WD) (control group). In dependence on the type of GSD patients of the main group were divided into 3 groups: 1st with GSD Type I (n = 18), 2nd - with GSD type III (n = 21), the third - with the GSD type VI/IX (n = 20). Reference group was consisted of 107 children without liver disease. CT of the abdominal cavity on multislice computed tomography Light Speed 16 and 750 HD (GE, USA) was performed in all cases. The pronounced hepatomegaly with predominant increase in the left lobe and the index of I segment was established to be the common diagnostic CT sign, typical for all types of GSD. The change in the X-ray density of the liver parenchyma, dependent on the type of disease is also the feature of the CT-picture of liver parenchyma. In GD type I there was often noted the decline in the X-ray density of the liver parenchyma, while in GSD types III and VI there was identified a significant increase in the density of the organ tissue, which was related with morphological changes in the liver parenchyma, caused by the deposition of glycogen in hepatocytes, fat and protein dystrophy. The authors believe that CT of the abdominal cavity can be an alternative, non-invasive, relatively inexpensive and accessible way to diagnose GD, which is especially important in pediatric practice.