Open AccessComprehensive ultrasound diagnosis in the evaluation of liver parenchyma and stages of fibrosis in children with autoimmune hepatitis
Author(s) -
Galina M. Dvoryakovskaya,
S. A. Ivleva,
I. V. Dvoryakovskiy,
А.Н. Сурков,
А. С. Потапов,
О. С. Гундобина,
И. Е. Смирнов
Publication year - 2019
Publication title -
rossijskij pediatričeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2413-2918
pISSN - 1560-9561
DOI - 10.18821/1560-9561-2016-19-1-4-8
Subject(s) - medicine , ultrasound , cirrhosis , autoimmune hepatitis , parenchyma , transient elastography , fibrosis , liver fibrosis , hepatic fibrosis , pathology , radiology , liver parenchyma , hepatitis , gastroenterology
There are presented data of the comprehensive ultrasound examination of 88 children, aged from 3 to 16 years, with autoimmune hepatitis (AIH), types 1 and 2. There was performed a comparative evaluation of morphological and ultrasound (US) changes in the structure of the liver parenchyma in 67 children with AIH with the use of non-invasive ultrasound techniques Acoustic Structure Quantification (Live ASQ) for transient elastography of the liver (TEL) and quantitative estimation of the structure of the liver parenchyma. It was established that in 5 patients the mean value of the density index (DI) was equal to 1.69, and the elasticity of 5.40 kPa, that corresponded on data of the morphological study to minimal and moderate fibrosis according to the METAVIR scoring system (F1-2). In advancedfibrosis in 19 children with AIH DI in average was equaled to 2.47 and values of elasticity were 10.90 kPa (F3). In 49 patients at the stage of liver cirrhosis (LC) (F4) the elasticity value was 26.10 kPa and DI - 3.63. These consistencies indicate to the diagnostic significance of ultrasound non-invasive techniques ASQ and TEL and the appropriateness of their use in pediatrics.