Open AccessDRUGS CONTAINING GLYCYRRHIZIC ACID IN COMPLEX THERAPY FOR PULMONARY TUBERCULOSIS
Author(s) -
Дмитрий Сергеевич Рясенский,
N. A. Grishkina,
Alexander Aseev
Publication year - 2019
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.18821/1560-9529-2019-24-3-118-122
Subject(s) - tolerability , medicine , peripheral blood mononuclear cell , tuberculosis , pharmacology , chemotherapy , immunology , pathology , in vitro , biochemistry , chemistry , adverse effect
The effectiveness of etiotropic chemotherapy is largely determined by the tolerability o the TB drugs (TBD) and the severity of unwanted side effects. It is known about the immunopathological effect of TBD, which can also be attributed to the undesirable effects of anti-tuberculosis chemotherapy. Changes in the structure and composition of mononuclear membranes reflect their functional activity. Secondary disorganization of the lipid bilayer due to the action of TBD is an important element in the development of immunosuppressive conditions in pulmonary tuberculosis and requires specific correction. The paper has the results of a survey of 308 patients with tuberculosis included. The comparison group consisted of 36 healthy volunteers. The membrane destruction coefficient and cholesterol-phospholipid ratio were used in order to assess the state of peripheral blood mononuclear cells and the degree of structural disorganization of their membranes. The prescription of preparations containing glycyrrhizic acid is pathogenetically substantiated and allows improving the state of the membranes of mononuclear cells, thereby reducing the undesirable membrane-toxic effect of first-line anti-tuberculosis drugs, There was an increase in etiotropic therapy intensity on the basis of abacilation at the end of the intensive phase of the main course of chemotherapy from 61% to 72.4% when using Licorice Root, and to 81.3% when using Fosfogliv® in patients with focal and infiltrative pulmonary tuberculosis.