Open AccessDIAGNOSTIC SIGNIFICANCE OF ANTIBODIES SPECTRUM TO COXIELLA BURNETII IN I AND II PHASES
Author(s) -
T. A. Chekanova,
С. Н. Шпынов,
S. Zh. Netalieva,
M. A. Babaeva
Publication year - 2018
Publication title -
èpidemiologiâ i infekcionnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2411-3026
pISSN - 1560-9529
DOI - 10.18821/1560-9529-2019-23-4-165-171
Subject(s) - coxiella burnetii , q fever , serology , antibody , immunoglobulin m , immunology , virology , medicine , context (archaeology) , immunoglobulin g , respiratory tract infections , respiratory system , biology , paleontology
The article discusses the results of a retrospective study for the presence of Coxiellosis serological markers in 723 blood sera from 537 febrile patients hospitalized in May-September 2015 in the regional infectious hospital in the Astrakhan region. Blood sera were screened by ELISA for the presence of IgG and IgM to II phase Coxiella burnetii (IgG II and IgM II, respectively). Samples, containing IgG II, wear detected IgG to I phase C. burnetii (IgG I). 92 seropositive C. burnetii patients (including 15 children’s) were identified. Characteristics of the antibody profiles in this study (IgG II, IgG II + IgM II, IgG II + IgG I, IgG II + IgM II + IgG I, IgM II) and their titers were given. The clinical picture is typical for acute infectious diseases was more often noted (diagnoses - acute respiratory disease / acute respiratory viral infection, adenovirus infection, Astrakhan spotted fever, coxiellosis) at spectrum detecting IgM II, IgM II + IgG II or IgG II (1: 800-1: 1600 titters). The «unknown etiology viral infection» diagnosis was more common among adults with any possible antibodies spectrum. Diagnostic criteria of acute Q fever and chronic coxsiellosis are discussed in the context of the serological testing results.