Open AccessGENETICS OF VESICOURETERAL REFLUX
Author(s) -
Dmitry Shakhnovskiy,
S. N. Zorkin,
Kirill V. Savost’anov,
А. А. Пушков
Publication year - 2018
Publication title -
detskaâ hirurgiâ
Language(s) - English
Resource type - Journals
eISSN - 2412-0677
pISSN - 1560-9510
DOI - 10.18821/1560-9510-2018-22-4-193-198
Subject(s) - vesicoureteral reflux , medicine , incidence (geometry) , population , urinary system , pediatrics , disease , reflux , physics , environmental health , optics
Primary vesicoureteral reflux (VUR) is known to be the most common urological anomaly in children, witch affects 1-2% of pediatric population and 30-40% of children, developing urinary tract infections (UTIs). The hereditary and familial nature of VUR is well established and in several studies was proved that siblings of children with VUR have a higher incidence of reflux than it is in general pediatric population. Familial clustering of VUR implies that genetic factors have an important role in its pathogenesis, but to date no single major locus or gene for VUR has been identified and most researchers acknowledge that VUR is genetically heterogeneous. Improvements in genome wide scan techniques and continuously increasing knowledge of the genetic basis of VUR should lead us to further insights on VUR pathogenesis.