Open AccessComparative analysis of the receptor status of the primary focus and synchronous axillary metastases in breast cancer patients
Author(s) -
Yu. S. Krumin,
В. А. Хайленко,
Н. А. Козлов,
G. Yu. Cheremis,
Д. В. Хайленко,
Е. В. Артамонова,
Е. И. Коваленко,
И. П. Коваленко,
В. Ю. Бохян
Publication year - 2020
Publication title -
rossijskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9119
pISSN - 1028-9984
DOI - 10.18821/1028-9984-2019-24-3-6-74-78
Subject(s) - medicine , breast cancer , concordance , oncology , pathological , progesterone receptor , estrogen receptor , hormone receptor , cancer , gynecology
The aim of the investigation. To study concordance of surrogate molecular subtype in the pairs of primary and synchronous axillary metastases in patients with invasive breast cancer (IBC).
Materials and methods. Retrospective analysis included 80 patients aged 28 to 90 years (average age 40.35.3 years) with a first-time diagnosed IBC who underwent surgical treatment at the N.N. Blokhin National Medical Research Center of Oncology during 20162018 years. None of the patients received any neoadjuvant drug therapy. The pathological evaluation of the estrogen receptors (ER), progesterone receptor (PR), HER2 expression and estimation of proliferative activity (Ki-67 index) with subsequent assignment to surrogate subtypes were performed according to ASCO/CAP protocols and the recommendations of the 20132019 San-Gallen Conference on treatment of Early Breast Cancer.
Results. Preliminary results of our study revealed therapeutically significant changes in hormone receptor status, HER2-status and proliferative activity in 12.5% of cases of Luminal A type IBC, 20% of Luminal B/HER2-positive and 4% of Luminal B/Her2-negative subtypes of IBC.