Open AccessSkin melanoma. State of the problem. Review
Author(s) -
S. A. Yаrgunin,
А. Ф. Лазарев
Publication year - 2020
Publication title -
rossijskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9119
pISSN - 1028-9984
DOI - 10.18821/1028-9984-2019-24-3-6-113-120
Subject(s) - medicine , melanoma , disease , intensive care medicine , incidence (geometry) , skin cancer , cancer , dermatology , pathology , cancer research , physics , optics
Skin melanoma, being the deadliest form of skin tumor, contributes significantly to cancer mortality and carries a significant and growing public health burden. The incidence of MK is growing steadily throughout the world and is in the nature of a silent epidemic. The critical mortality rate is due to the high metastatic potential of the tumor and the low efficiency of systemic therapy of disseminated forms of the disease. Thanks to a breakthrough in understanding the genetic mechanisms of the appearance of a tumor, the spread and tolerance to treatment, the emergence of a number of targeted and immunological drugs, patients with advanced MK have the hope of prolonging life and even complete cure. However, many diagnostic problems remain; treatment standards; emerging tolerance to therapy. All these questions compel further research into the diagnosis and treatment of this disease.