Open AccessBIOPSY OF SIGNAL LYMPHATIC NODULES IN PATIENTS WITH BREAST CANCER AFTER NEOAVARIANT CHEMOTHERAPY
Author(s) -
Е.М. Бит-Сава,
Бит-Сава Елена Михайловна,
М Г Анчабадзе,
Анчабадзе М. Г,
М А Моногарова,
Моногарова М. А,
В. Моисеенко,
Моисеенко В. М
Publication year - 2018
Publication title -
rossijskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9119
pISSN - 1028-9984
DOI - 10.18821/1028-9984-2018-23-3-4-116-119
Subject(s) - medicine , biopsy , sentinel lymph node , lymph , breast cancer , axillary lymph nodes , lymph node , chemotherapy , lymphatic system , cancer , oncology , radiology , adjuvant therapy , pathology
One of the advantages of systemic cytotoxic therapy is the «transformation» of positive axillary nodes into negative nodes (cN+ → cN-); a similar concept is used in randomized clinical trials with «post-neoadjuvant» sentinel lymph node - pNsn. In studies of ACOSOG Z1071, SENTINA, SN FNAC, was evaluated the frequency of a false-negative result with a biopsy of the sentinel lymph node (BSLU) after neodjuvant chemotherapy. It was proved that there was no need for immunohistochemical examination of lymph nodes using the BSLU technique followed by adjuvant therapy, since the detected micrometastases did not worsen overall survival. As for patients with biopsy of signaling lymph nodes after neodjuvant chemotherapy, nowadays particular interest of prognostic in significance for micrometastases and individual tumor cells in the lymph nodes, as well as an estimate of the frequency of false-negative result.