Open AccessASSOCIATION OF THE FOLATE METABOLISM GENES WITH THE RISK FOR LUNG, PROSTATE, BREAST AND UTERINE CANCER
Author(s) -
А. Н. Шилова,
Ольга Сергеевна Шкода,
В. В. Ломиворотов,
Ju.N. Shilova
Publication year - 2017
Publication title -
rossijskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9119
pISSN - 1028-9984
DOI - 10.18821/1028-9984-2017-22-4-203-208
Subject(s) - mtrr , methylenetetrahydrofolate reductase , lung cancer , breast cancer , prostate cancer , medicine , oncology , genotype , cervical cancer , cancer , allele , gene , biology , genetics
We examined 324 patients with various oncological diseases (157 patients with prostate cancer, 54 - with lung cancer, 47 - with uterine cancer, 42 - with cervical cancer and 24 patients - with breast cancer) and 391 relatively healthy donors. We investigated the frequency of key polymorphisms of folate metabolism genes (MTHFR: 677 C>T (Ala222Val); MTHFR: 1298 A>C (Glu429Ala); MTR: 2756 A>G (Asp919Glu); MTRR: 66 A>G (Ile22Met)). Analysis revealed no differences in the frequency of all examined gene polymorphisms and alleles between patients with oncological diseases and relatively healthy donors. All investigated genotypes and alleles of key folate cycle genes were not associated with the risk for the development of oncological diseases.