Open AccessTHE SEPSIS-INDUCED ENCEPHALOPATHY
Author(s) -
Sofiya M. Rhalib,
Sergey V. Sviridov,
Irina V. Vedenina,
V. S Nekrasova
Publication year - 2018
Publication title -
rossijskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9100
pISSN - 0869-2106
DOI - 10.18821/0869-2106-2018-24-2-99-103
Subject(s) - sepsis , encephalopathy , delirium , coma (optics) , medicine , intensive care medicine , pathophysiology , physics , optics
The article presents a review of publications concerning sepsis-induced encephalopathy. The sepsis-induced encephalopathy is a disorder of cognitive functions frequently occurring in sepsis without any relationship with inflammation central nervous system. This condition is an actual problem against the background of increasing of number of patients with infection and sepsis. The main pathophysiologic mechanism of sepsis-induced encephalopathy is considered derangement of hematoencephalic barrier and also increasing of concentration of aromatic amino acids. The clinical symptomatic of hematoencephalic barrier is characterized by disorder of consciousness level and also by disorders of sleep, deficiency of attention, delirium down to coma. To confirm diagnosis of sepsis-induced encephalopathy various diagnostic scales are applied and instrumental and laboratory diagnostic techniques. In treatment of the given pathology key positions are elimination of infection and correction of metabolic disorders.