Open AccessTHE CLINICAL PHARMACOKINETIC PARALLELS OF PERI-OPERATIONAL ANTIBIOTICS PREVENTION IN ABDOMINAL SURGERY
Author(s) -
А. Б. Ларичев,
A. R Babadzhanyan,
А. Н. Фомин,
V. B Kryuchkov,
Konstantin Nikolaevich Efremov,
Anna Smirnova
Publication year - 2018
Publication title -
rossijskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9100
pISSN - 0869-2106
DOI - 10.18821/0869-2106-2018-24-2-73-77
Subject(s) - cefoperazone , medicine , pharmacokinetics , subcutaneous tissue , inguinal hernia , antibiotics , surgery , anesthesia , hernia , antibiotic resistance , imipenem , microbiology and biotechnology , biology
The purpose of study is to evaluate features of pharmacokinetics and efficiency of cefoperazone as a mean of peri-operational antibiotic prevention under surgical treatment of ventral hernia. Material and methods. The results of herniotomy and meshed endoprosthesis replacement were analyzed in 459 patients who, 20 minutes before the operation, received intravenous bolus injection of 1 g of cefoperazone with purpose of preventing wound infection. The pharmacokinetics of medication was analyzed according developed technique of capillary electrophoresis using device KAPEL-105M («Lumex», St. Petersburg). The analysis was applied to blood, urine and tissues of wound (skin, subcutaneous cellular tissue, aponeurosis, muscle, peritoneum) taken after 20, 40 and 60 minutes after injection of cefoperazone. The results. The first stage of study established that content of cefoperazone in subcutaneous fat is as much as possible approximated to its concentration in blood and it is 2-3 times higher in peritoneum. At the 60th minute a higher level of cefoperazone is observed in all tissues except subcutaneous cellular tissue though it is most stable there. At that, wound complications are established in 9 (1.95%) patients, including 2 (0,44%) patients шт the form of seroma. Discussion. In case of intravenous injection cefoperazone is distributed in tissues in the way that up to 60th minute of study, a significant decreasing of medication level (p