Open AccessTHE METABOLIC DISORDERS IN MEMBRANE OF ERYTHROCYTES AND INSULIN-BINDING ACTIVITY OF BLOOD CELLS IN PATIENTS UNDER OBESITY AND DIABETES MELLITUS TYPE II
Author(s) -
N. P. Mikaélyan,
Микаелян Нина Погосовна,
Vladimir Vasilievich Potemkin,
Потемкин В. В
Publication year - 2017
Publication title -
rossijskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2412-9100
pISSN - 0869-2106
DOI - 10.18821/0869-2106-2017-23-4-201-204
Subject(s) - medicine , endocrinology , type 2 diabetes mellitus , diabetes mellitus , obesity , insulin , metabolic disorder , cholesterol , insulin resistance , blood lipids , metabolism , chemistry
The results of clinical metabolic examination of women with diabetes mellitus type II and patients with obesity degree III-IV testify increasing of level of cholesterol, triglycerides, low density lipoproteins and very low density lipoproteins and also coefficient of atherogenity in comparison with control group. These alterations permit to affirm that diabetes mellitus type II in women also as obesity is accompanied by dislipidemia of atherogenic character. At that, in patients with diabetes mellitus type II more intensive alterations of quantitative composition of lipids, including fat acid composition of blood is established. The obesity and diabetes mellitus type II are accompanied by modification of composition of free and esterified fatty acids of blood erythrocytes, increasing of peroxidation of lipids that can result in alteration of functional activity of membranes and in damage of insulin-binding activity of cyto-membranes. The disorder of metabolism of fatty acids accompanied by increasing of concentration of free radicals and decreasing of activity of enzymes of anti-oxidant defense results in decreasing of insulin-binding activity of cells and disorder of processes of glucose utilization.