Open AccessMETHOD FOR PREDICTING PERINATAL HYPOXIC LESIONS OF THE CENTRAL NERVOUS SYSTEM IN NEWBORNS
Author(s) -
Anna Smirnova,
N.Yu. Borzova,
Н. Ю. Сотникова,
А. И. Малышкина,
Evgenij Bojko
Publication year - 2019
Publication title -
kliničeskaâ laboratornaâ diagnostika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.12
H-Index - 10
eISSN - 2412-1320
pISSN - 0869-2084
DOI - 10.18821/0869-2084-2019-64-2-89-93
Subject(s) - medicine , perinatal period , central nervous system , fetus , lesion , venous blood , nervous system , obstetrics , perinatal mortality , pregnancy , physiology , hypoxia (environmental) , pediatrics , pathology , biology , chemistry , genetics , organic chemistry , psychiatry , oxygen
Perinatal lesions of the Central nervous system (CNS) in newborns occupy a leading place in the structure of perinatal morbidity and subsequent disability of children. To identify the features of the content of sRAGE in pregnant women with threatening preterm labor (UPR) in the period of 22-27 weeks, who subsequently gave birth to children with perinatal CNS lesion. Serum of venous blood of pregnant women with UPR at the term of 22-27 weeks was determined by ELISA once the content of sRAGE. If the value of sRAGE in pregnant women is 659.5 PG/ml or less, perinatal hypoxic lesions of the Central nervous system in newborns are predicted with an accuracy of 75.8% (sensitivity of 82.6%, specificity of 66.7%).