Open AccessInfluence of the immunomodulatory drug stimforte on the humoral immune response in the experimental herpes virus infection
Author(s) -
Д Г Мальдов,
В. Л. Андронова,
А. А. Балакина,
А. В. Ильичев,
Г. А. Галегов
Publication year - 2016
Publication title -
voprosy virusologii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 15
eISSN - 2411-2097
pISSN - 0507-4088
DOI - 10.18821/0507-4088-2016-61-4-172-175
Subject(s) - vero cell , virology , immune system , antibody , virus , neutralization , western blot , glycoprotein , immunology , biology , drug , antiviral drug , herpes virus , microbiology and biotechnology , pharmacology , biochemistry , gene
In the study of the immunostimulation preparation Stimforte activity using the model of the experimental herpes virus infection BALB/c, mice has shown that sera from mice treated with the drug on the 4th and 7th day after infection possessed a 3 times greater capability of specifically binding to the culture of HSV-1 (on cells Vero) according to dot blot analysis, as compared with intact infected mice sera obtained at the same time. It was also shown that these sera had a 5 times higher index of neutralization. On the basis of Western blots, it was detected that antibodies from sera of mice treated with Stimforte contacted the glycoproteins gB and gC of HSV-1 significantly better. Thus, Stimforte stimulates one of the strongest modulatory effects on the immune memory and is a promising drug for the treatment of chronic viral diseases.