Factors associated with development stroke in patients after acute coronary syndrome without ST elevation in the five-year follow-up.

. Recently there has been an active growth in disability of the population due to cases of development of acute cerebrovascular accident (ischemic stroke). Therefore, great attention is given to risk factors for the development of ischemic stroke, including in patients after acute coronary syndrome (non-ST-ACS). Objective: to study the contribution of clinico-laboratory factors associated with the development of acute cerebrovascular accident in patients with non-ST-ACS during five years follow-up. Material and methods. 415 patients were included in the register of patients with non-ST-ACS (2009-2010). The follow-up period was 60 months. In addition to the generally accepted clinical and laboratory examination, patients were assessed the factors of nonspecific inflammation and oxidative metabolism of lipids on the 11th -13th day of hospitalization with ASC. Results. In 29 (7.70%) of the patients with OCSUPST included in the study, ischemic stroke developed over a five-year follow-up period. Significantly, ischemic stroke developed in patients with ischemic stroke in anamnesis (p=0.008) and myocardial infarction (p=0.027), rhythm disturbances about the type of atrial fibrillation-flutter (AF/TP) (p = 0.005) and GRACE-score risk on admission (p=0.00015), higher blood levels of interleukin (IL)-6 (p = 0.01), and IL-10 (p = 0.007), as well as a high average heart- ankle index (p = 0.019). Conclusion. Logistic regression results revealed the most significant adverse factors affecting the development of the ischemic stroke in the long-term follow-up period, after an acute coronary syndrome without an ST segment elevation: an elevated blood concentration of IL-6> 8.0 pg/ml, the presence of atrial fibrillation/flutter, the ischemic stroke in the anamnesis.