Open AccessFor fulminant rapidly progressive glomerulonephritis in a 17-year-old female patient with ANCA-associated vasculitis.
Author(s) -
N B Gordovskaya,
Eugene Shilov,
Yu.V. Korotchaeva,
Ekaterina V. Stavrovskaya,
S. V. Roshchupkin
Publication year - 2018
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2018-96-2-180-185
Subject(s) - rapidly progressive glomerulonephritis , glomerulonephritis , medicine , vasculitis , fulminant , pathology , anti neutrophil cytoplasmic antibody , hemodialysis , microscopic polyangiitis , antibody , immunology , kidney , disease
A case of rapidly progressive glomerulonephritis in a 17-year-old patient associated with antibodies against the cytoplasm of neutrophils (ANCA) vasculitis - ANCA-associated vasculitis is associated with antibodies to proteinase-3 and morphological picture extracapillar glomerulonephritis with sclerotic lesion of up to 80% of the glomeruli. The peculiarity of the case is the presence of morphologically confirmed when alloimmune rapidly progressive glomerulonephritis type III a pronounced glow-focal granular nature of immunoglobulin classes G and M on the basement membrane of capillaries. The appointment of immunosuppressive therapy led to a decrease in systemic manifestations of vasculitis, but there was a rapid increase in terminal renal failure, which required substitution therapy with hemodialysis. The possible mechanisms of the rapid-training course of the disease in the observed patient, prospects for kidney transplantation are discussed.