Open AccessSystemic endotoxemia in patients with chronic kidney disease.
Author(s) -
Aleksei Zulkarnaev
Publication year - 2018
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2018-96-1-13-19
Subject(s) - medicine , pathogenesis , kidney disease , systemic inflammation , kidney , disease , dialysis , urinary system , homeostasis , hemodialysis , peritoneal dialysis , inflammation , microbiome , immunology , bioinformatics , biology
Endotoxin plays an important role in the pathogenesis of atherosclerosis, metabolic syndrome, and other processes contributing significantly to mortality in patients with chronic kidney disease. Developing on the background of systemic endotoxemia chronic inflammation, causing numerous violations of adaptive-compensatory mechanisms of homeostasis regulation. The main source of endogenous endotoxin is the gut microbiome. The severity of endotoxemia increases with the progression of chronic kidney disease. In patients on hemodialysis endotoxinemia also associated with the use of high permeable membranes. Of particular importance in this case is the formation of biofilm in the dialysis lines, water purification system and central venous catheters. Targeted prevention of complications associated with systemic endotoxemia may improve outcomes in patients with chronic kidney disease.