Open AccessA. Diagnostic and prognostic value of detection of the N-terminal fragment of brain
natriuretic peptide in type 2 diabetes mellitus
Author(s) -
A.F. Verbovoy Verbovoy,
Natal’ya A. Barabanova
Publication year - 2017
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2017-95-6-553-557
Subject(s) - medicine , heart failure , diabetes mellitus , ejection fraction , cardiology , glycated hemoglobin , natriuretic peptide , type 2 diabetes mellitus , type 2 diabetes , brain natriuretic peptide , concomitant , creatinine , endocrinology
Detction of chronic heart failure at the stage of reversible changes can prevent the development of cardiovascular complications, reduce morbidity and mortality in patients with type 2 diabetes mellitus. The aim of our study was to explore the level of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and to evaluate the possibility of using this marker in diagnostics of chronic heart failure in patients with type 2 diabetes. The study included 60 patients with type 2 diabetes and concomitant chronic heart failure. All patients underwent echocardiography, blood glucose and glycated hemoglobin, creatinine, and NT-proBNP measurement. All patients with diabetes mellitus were shown to have elevated NT-proBNP levels in comparison with the control group. We established negative correlation of this parameter with the left ventricular ejection fraction and inverse correlation between NT-proBNP and blood glucose. The study confirmed the value of NT-proBNP measurement for diagnostics of CHF but demonstrated low specificity of this test for the assessment of severity (functional class) of CHF in patients with type 2 diabetes.