Open AccessIdiopathic pulmonary fibrosis as a possible exrtraesophageal manifestation of
gastroesophageal reflux disease
Author(s) -
В. А. Ахмедов,
О. В. Гаус,
D Petrov
Publication year - 2017
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2017-95-5-389-393
Subject(s) - idiopathic pulmonary fibrosis , medicine , pathological , etiology , pathophysiology , reflux , disease , fibrosis , pulmonary fibrosis , pathology , inflammation , pathogenesis , gastroenterology , lung , immunology
Idiopathic pulmonary fibrosis (IPF) is a most widespread clinic-morphological variant of Idiopathic interstitial pneumonias. Its pathophysiology includes recurrent damages to epithelial cells and anomalous reparative reaction in response to aseptic inflammation in the form of excess fibroblast proliferation. The cause of epithelium damage remains unknown; the involvement of smoking, viral infections, inhaled pollutants, and toxic drug n the initiation of the pathological process is conjectured. Numerous studies of recent years suggest the potential role of gastroesophageal reflux and microaspiration as etiological factors of IPF progression. A brief review of modern views of the relationship between IPF and gastroesophageal reflux is presented.