Open AccessClinical features and results of laboratory and instrumental examination of
patients with nodular structures in the thyroid gland in real clinical practice
Author(s) -
I. S. Berezkina,
Т. В. Саприна,
А. П. Зима,
А В Исаева,
В. Н. Латыпова,
И. Н. Ворожцова,
М. Р. Мухамедов,
Leonid R. Bazilevich,
О. С. Попов,
С. В. Лунева,
N. G. Zav'jalova
Publication year - 2017
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2017-95-4-355-361
Subject(s) - thyroid nodules , overdiagnosis , medicine , thyroid , malignancy , goiter , differential diagnosis , radiology , thyroid cancer , physical examination , pathology
The ever increasing incidence of thyroid cancer throughout the world poses the problem of differential diagnosis of thyroid nodules at various stages of their formation. Objective: to determine the most important clinical, laboratory and instrumental parameters of thyroid nodules for the assessment of their malignancy potential and to identify "defects" of clinical and instrumental examination of patients with nodular goiter in clinical practice. Materials and methods: we analyzed the data of general clinical research, hormonal profile, and thyroid ultrasound studies performed on the basis of various clinics in the city of Tomsk (41%), Endocrinology Department of the OGAUZ TOKB consultative and diagnostic polyclinic (28 %), and Cancer Research Institute (31%) for the period from 2012 to 2014. The patients were selected for surgery. Pre-operative data were compared with histological features of the nodules. Results: we analyzed «defects» of patient examination, statistical data on clinical and laboratory-instrumental parameters of thyroid nodules. Conclusion: «defects» of description of ultrasound data significantly reduce sensitivity of the method for predicting malignancy of thyroid nodules. The description of the material obtained by US-FNA alone, in the absence of the conclusion of medical cytologists, has no informative value. Low specificity of a cytological study (48.4%) and its high sensitivity (95.8%) suggests overdiagnosis of thyroid cancer.