Open AccessMelatonin: the possibility to analyze the marker of age-related pathology in buccal epithelium and urine
Author(s) -
S. Konovalov,
V. I. Polyakova,
А О Дробинцева,
I. M. Kvetnoy,
Т В Кветная,
N. S. Linkova
Publication year - 2017
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2017-95-2-136-139
Subject(s) - melatonin , endocrine system , urine , buccal swab , buccal administration , macular dystrophy , endocrinology , medicine , physiology , metabolite , pathology , biology , hormone , pharmacology , retinal , ophthalmology , genetics
Extrapineal and pineal melatonin is the marker of the aging rate of organism making it possible to characterize functional condition of the neuro-immuno-endocrine system. In this article we have used the new method for non-invasive diagnostics of melatonin expression in buccal epithelium and determination of the main melatonin metabolite 6-hydroxymelatonin sulfate (6-HMS) in urine of elderly people. Normal, impaired and enhanced melatonin expression was documented in 20.5%, 43.2% and 36.30% of the patients respectively. Such comprehensive melatonin and 6-COMT studies can be recommended for elderly patients with oncological, neurodegenerative, cardiovascular diseases, and ageing macular dystrophy. Moreover, melatonin expression analysis in buccal cells can be used for integral investigation of biorhythms in elderly people.