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Efficacy of combined therapy of non-alcoholic fatty liver disease with succinate-containing drugs
Author(s) -
В В Стельмах,
Anna S. Nekrasova,
В К Козлов,
M. Ja. Kotiv,
Mari. Karpenko
Publication year - 2017
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2016-94-11-836-842
Subject(s) - medicine , fatty liver , tolerability , cholestasis , drug , triglyceride , gastroenterology , pharmacology , cholesterol , disease , adverse effect
Aim. To study the safety and tolerability of combined pathogenetic therapy of non-alcoholic fatty liver disease with the use of succinate-containing drugs (remaxol, cytoflavin) and its influence on the functional state of liver and lipid metabolism in patients with non-alcoholic steatohepatitis (NASH) and metabolic syndrome. Materials and methods. The study included 62 patients (52% men and 48% women) at the mean age of 50,18±2,38 yr. The treatment included electrolyte solutions, vitamins, enzymes, herbal preparations (milk thistle), essential phospholipids, antihypertensive drugs, and a course of infusion therapy with a metabolic corrector showing hepatoprotective activity (remaxol, 400 ml i/v for 11 days). Patients with hyperenzymemia were additionally given 1-3 courses of therapy with oral succinate-containing cytoprotector cytoflavin (1 tablets t.p.d for at least 10 days per month during a total of 6 months). If appropriate (signs of cytolysis and cholestasis) remaxol therapy was repeated once in 6 months with subsequent transition to oral cytoflavin till complete regression of hyperenzymemia. Results. 74% of the patients treated with remaxol and cytoflavin experienced normalization of enzymemia (ALT and AST). Triglyceride levels decreased to the normal values in 39% of the cases. Conclusion. Inclusion of succinate-containing drugs (remaxol, cytoflavin) in combined treatment of NASH and metabolic syndrome promotes normalization of hepatic function and has marked lipid-regulating effect.

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