Open AccessThe role of free radical oxidation and inflammation in the development of post-pericardiotomy syndrome after coronary heart disease artery bypass grafting
Author(s) -
В. В. Внуков,
Р В Сидоров,
N. P. Milyutina,
A. A. Ananyan,
D. Yu. Pospelov,
Dmitry Y. Gvaldin,
В. Н. Щетко
Publication year - 2017
Publication title -
kliničeskaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2412-1339
pISSN - 0023-2149
DOI - 10.18821/0023-2149-2016-94-11-827-831
Subject(s) - proinflammatory cytokine , medicine , lipid peroxidation , antioxidant , bypass grafting , artery , inflammation , cardiology , revascularization , surgery , oxidative stress , biochemistry , chemistry , myocardial infarction
The purpose of this research was the clinical biochemical study of the role of the antioxidant system, products of lipid peroxidation and proinflammatory mediators in the mechanisms of development of postpericardiotomy syndrome. 50 patients who underwent coronary-artery bypass grafting were examined. They were divided into two groups: those without postpericardiotomy syndrome (1) and patients with this syndrome (2). The results suggest tension of the antioxidant system, overproduction of proinflammatory interleukin-6 and intensification of free radical oxidation in the patients undergoing direct myocardial revascularization.