z-logo
open-access-imgOpen Access
ON THE POSSIBLE PARTICULARITY OF HELICOBACTER PYLORI INFECTION TO GALLSTONE DISEASE
Author(s) -
С. В. Герман,
А. В. Модестова,
И. Е. Зыкова,
Igor P. Bobrovnitsky,
M. Yu. Yakovlev
Publication year - 2018
Publication title -
gigiena i sanitariâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 13
eISSN - 2412-0650
pISSN - 0016-9900
DOI - 10.18821/0016-9900-2018-97-11-1076-79
Subject(s) - caga , virulence , helicobacter pylori , gallstones , antibody , medicine , incidence (geometry) , pathogen , helicobacter , immunology , disease , gastroenterology , microbiology and biotechnology , biology , gene , biochemistry , physics , optics
. Up to now, it has not been established whether Helicobacter pylori, the most common bacterial pathogen of human, is involved in cholelithiasis. Material and Methods. Based on the analysis of prophylactic medical examination of working people in the Moscow region, the determination the pyloric Helicobacter infection and assessment of the virulence of bacteria there were studied the associations of H. pylori infection and gallstones. The infection was detected by the presence of serum specific antibodies of IgG class, the virulence of the strain H. pylori - by the presence of total antibodies to the protein associated with the cytotoxic gene CagA. There was used enzyme-linked immunosorbent assay. The study included 1,487 people, 931 men and 556 women aged 21-77 years. Results. The H. pylori infection was detected in 1348 (90,6%), CagA protein in - 392 (56.2 %) cases. Gallstones were diagnosed in 72 patients, 21 men (2.3%) and 51 women (9.2%), 67 were seropositive (5% of all infected) and 5 - seronegative (3.6% uninfected). In cholelithiasis cases, the presence of CagA positive strain of H. pylori was investigated in 35 patients. A virulent strain of bacteria was detected in 26 cases (74%), much more often than in the rest examined persons. Conclusion. There were no statistically significant differences in the incidence of cholelithiasis in infected H. pylori and non-infected individuals. A significantly higher prevalence of infection with pathogenic strains of H. pylori in patients with gallstones was found in comparison with the whole group of examined patients, that indicates to the favor of possible involvement of H. pylori infection in this pathology. Confirmation of the role of H. pylori infection as a cumulative risk factor for the gallstones cholecystitis, as well as for other extragastral pathologies, may have an epidemiological, prophylactic, clinical application, due to its widespread prevalence. Further research is needed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here