Open AccessTHE INFLUENCE OF SMALL DOSES OF THE HERBICIDE 2,4-DICHLOROPHENOXYACETIC ACID ON THE BODY WEIGHT OF ANIMALS UNDER THE DIET WITH NORMAL OR HIGH CALORIE
Author(s) -
D. S. Karmanova,
Larisa A. Chesnokova,
С. И. Красиков
Publication year - 2019
Publication title -
gigiena i sanitariâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 13
eISSN - 2412-0650
pISSN - 0016-9900
DOI - 10.18821/0016-9900-2017-96-3-287-288
Subject(s) - 2,4 dichlorophenoxyacetic acid , endocrinology , body weight , medicine , weight gain , chemistry , zoology , leptin , thyroid , obesity , biology , botany
There was studied the effect of 6-weeks intake of small doses of the herbicide 2,4-DA on the body weight of animals. The consumption of water containing the herbicide in a concentration of 0.5 MPC was shown to have led to the greater gain of the body weight in experimental rats in comparison with the control. Simultaneously there was noted the gain of the mass of epididymal fat and increase in the concentration of leptin. This effect was more pronounced in rats treated with 2,4-DA, under the diet with high caloric content. The results obtained are likely to be associated with the disrupting action of the herbicide, leading, in particular, to the disturbance of the regulatory function of the thyroid gland and insulin resistance.