Open AccessRole of genetic polymorphism and differences in the detoxification of chemical substances in the human body
Author(s) -
Lyubov A. Mogilenkova,
V. R. Rembovskiy
Publication year - 2019
Publication title -
gigiena i sanitariâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 13
eISSN - 2412-0650
pISSN - 0016-9900
DOI - 10.18821/0016-9900-2016-95-3-255-262
Subject(s) - detoxification (alternative medicine) , xenobiotic , biotransformation , polymorphism (computer science) , genetics , gene , biology , allele , medicine , biochemistry , enzyme , pathology , alternative medicine
There are given modern views on the role of genetic polymorphism on the detoxification of chemical substances and individual sensitivity in workers to the development of diseases associated with xenobiotics metabolism disorders. In the search for genetic markers of occupationally caused diseases it is promising to study allelomorphs of genes responsible for the polyfunctional response of the human body, including genes involved in xenobiotic biotransformation. There is substantiated the expediency of compilation and introduction of genetic passports for stuff occupied at hazardous chemical enterprises.