Open AccessDetection of Outlying Subjects in Bioequivalence Trials
Author(s) -
Sumeet Saurav,
Cini Varghese,
Sidharth Jaggi,
Mohd Harun,
Devendra Kumar
Publication year - 2020
Publication title -
bhartiya krishi anusandhana patrika
Language(s) - English
Resource type - Journals
eISSN - 0976-4631
pISSN - 0303-3821
DOI - 10.18805/bkap202
Subject(s) - bioequivalence , outlier , medicine , statistics , bioavailability , identification (biology) , econometrics , mathematics , medical physics , pharmacology , biology , botany
Evaluation of veterinary medicinal products is one of the important areas where bioequivalence trials are conducted. One of the problems commonly encountered in bioequivalence trials is outlying subjects. These outlying data may occur either as unexpected observations or as the unusual subject who has extremely high or low bioavailability with respect to the reference formulation and may have dramatic effects on the bioequivalence test. Therefore, it is important to examine the data carefully for identification of outlying observations in bioequivalence studies. In this study we have developed another general approach, termed the Estimated Distance (ED), to the outliers’ detection problem.