Various Systemic Effects of MK-467, A Peripherally Acting α2-adrenoceptor Antagonist in Different Animal Species: An Overview | Zendy

Akash Akash | Zendy; Mohammad Shah Alam | Zendy; AMARPAL AMARPAL | Zendy

Open Access

Various Systemic Effects of MK-467, A Peripherally Acting α2-adrenoceptor Antagonist in Different Animal Species: An Overview

Author(s) -

Akash Akash,

Mohammad Shah Alam,

AMARPAL AMARPAL

Publication year - 2020

Publication title -

agricultural reviews

Language(s) - English

Resource type - Journals

eISSN - 0976-0741

pISSN - 0253-1496

DOI - 10.18805/ag.r-2065

Subject(s) - atipamezole , medicine , antagonist , bradycardia , sedation , agonist , anesthesia , pharmacology , nociception , medetomidine , heart rate , blood pressure , receptor

Most commonly used α2-adrenoceptor agonist shows adverse cardiovascular effects during anaesthesia. They mainly depress the cardiovascular system by provoking vasoconstriction followed by bradycardia. Although α2-adrenoceptor antagonist like atipamezole can reverse these effects along with that they also reverse the sedation and nociception. Concomitant administration of peripherally acting α2-adrenoceptor antagonist MK-467 can reverse the adverse cardiovascular effect of α2-adrenoceptor agonists without affecting the sedation and nociception. MK-467 has been successfully used in different animals like dogs, cats, sheep, horses along with different α2-adrenoceptor agonist drugs. This review aims to summarize the effects of MK-467 on sedation, cardiopulmonary system, the minimum alveolar concentration of different inhalant anaesthetics, plasma drug concentration, plasma glucose and insulin in different animals.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research