Open AccessThe role of cystatin C and various methods of glomerular filtration rate calculation in evaluation of renal dysfunction in children with acute infectious diarrhea
Author(s) -
O.L. Chugunova,
E.Yu. Grebenkina,
Д.В. Усенко,
И. И. Володина,
Е. В. Галеева,
E. A. Drozhzhin,
А.А. Korsunskiy,
N. Yu. Legoshina,
А.Д. Музыка,
M. I. Naryshkina,
Ludmila Pavlushkina,
А. S. Rykova
Publication year - 2021
Publication title -
alʹmanah kliničeskoj mediciny
Language(s) - English
Resource type - Journals
eISSN - 2587-9294
pISSN - 2072-0505
DOI - 10.18786/2072-0505-2021-49-018
Subject(s) - cystatin c , renal function , medicine , creatinine , gastroenterology , cystatin , urology , acute kidney injury , diarrhea , endocrinology
Rationale : Acute infectious diarrhea (AID) is the fourth leading cause of death among children 950 ng/ml) occurred in 18 patients (22%). In other patients level of serum cystatin C remained within the reference range or lower. The risk of acute kidney injury development based on two indicators - GFR according to the modified Schwartz equation and GFR according to the equation used cystatin C level - occurred in 4 (10%) patients aged 1-3 years and in 1 (2.5%) child in the age group 3-7 years; risk, based on one indicator - the calculation of GFR according to the formula using cystatin C - in 8 (20%) and 9 (22.5%) children, respectively, and based on the assessment of only GFR according to the modified Schwartz equation - in 3 (7.5%) children of both age groups. Conclusion : We have confirmed that the GFR values calculated with usage of unmodified Schwartz equation (1976) are higher than those calculated with usage of modified Schwartz equation (2009) and taking into account the level of cystatin C. Thus, usage of unmodified Schwartz equation for GFR calculation in infants and preschool children seems incorrect. Level of serum cystatin C is promising marker permitted to select patients with risk of acute kidney injury development among children in acute period of moderate AID.