Open AccessGROWTH PARTICULARS OF PITUITARY MACROADENOMAS WITH VARIOUS HORMONAL ACTIVITIES
Author(s) -
Irena Ilovayskaya,
Alexander Dreval,
Yu. G. Krivosheeva,
Л. И. Астафьева,
Г. А. Сташук
Publication year - 2016
Publication title -
alʹmanah kliničeskoj mediciny
Language(s) - English
Resource type - Journals
eISSN - 2587-9294
pISSN - 2072-0505
DOI - 10.18786/2072-0505-2016-44-4-451-456
Subject(s) - hormone , adenoma , magnetic resonance imaging , population , medicine , pituitary adenoma , growth hormone , prolactin , pituitary gland , endocrinology , physiology , radiology , environmental health
Background: Pituitary adenoma is not as infrequent as thought previously. The prevalence of macroadenomas in general population is up to 0.16–0.2%. Magnetic resonance imaging (MRI) is a method of choice in diagnosis of pituitary adenomas. Until now, specifics of imaging of pituitary adenomas with various hormonal activities have not been discussed. Aim: To analyze comparatively the size, volumes and growth direction in pituitary macroadenomas with various hormonal activities. Materials and methods: We analyzed MRI images of 305 patients with hypophyseal adenomas of more than 10 mm diameter, among them with non-functioning adenomas (n=109), prolactinomas (n=58), and somatotropinomas (n=138). Results: Depending on their hormonal activity, hypophyseal adenomas had different volumes (р 0.05). Non-functioning hypophyseal adenomas and prolactinomas demonstrated mostly suprasellar growth (in 83.5 and 79.3% of cases, respectively), whereas somatotropinomas were growing mostly in infrasellar direction (66.1%). Conclusion: These characteristic features of hypophyseal macroadenomas with various hormonal activities could be used for differential diagnosis, which may help to optimize patient assessment during the diagnostic work-up.