Open AccessProcollagen propeptides and visceral obesity index in patients with myocardial infarction with preserved emission faction and various metabolic phenotype
Author(s) -
А. В. Осокина,
В. Н. Каретникова,
О. М. Поликутина,
Ю. С. Слепынина,
О. В. Груздева,
Т. П. Артемова,
С. Н. Рыженкова,
Tamara Pecherina,
О. Л. Барбараш
Publication year - 2020
Publication title -
translâcionnaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2410-5155
pISSN - 2311-4495
DOI - 10.18705/2311-4495-2020-7-1-22-32
Subject(s) - procollagen peptidase , protein precursor , medicine , ejection fraction , myocardial infarction , cardiology , fibrosis , endocrinology , myocardial fibrosis , heart failure , biology , enzyme , biochemistry
Purpose. To identify the peculiarities of the dynamics of fibrosis markers of C-terminal procollagen propeptide type I (PICP) and N-terminal collagen propeptide type III (PIIINP) in patients with ST segment elevation myocardial infarction (STEMI) and preserved myocardial contractility. Material and methods. 86 patients with STEMI and preserved left ventricular ejection fraction were examined. In addition to the standard laboratory and instrumental examinations, all the patients underwent the estimation of the concentrations of C-terminal procollagen propeptide type I (PICP) and N-terminal collagen propeptide type III (PIIINP) by enzyme-linked immunoassay using BCM Diagnostics laboratory kits (USA) on the 1st and the 12th days of disease and 1 year later. Results. The concentration of PICP was significantly reduced in all groups during the entire observation period. Significant correlations were found between PICP and visceral obesity index, age and left ventricular ejection fraction. A relationship was found between PIIINP and an increased visceral obesity index.