Open AccessADIPONECTIN AS AN ENDOGENOUS REGULATOR OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS
Author(s) -
Julian R. Ryzhov,
А. О. Шпаков
Publication year - 2018
Publication title -
translâcionnaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2410-5155
pISSN - 2311-4495
DOI - 10.18705/2311-4495-2018-5-5-26-36
Subject(s) - adiponectin , endocrinology , medicine , adipokine , energy homeostasis , hypothalamus , gonadotropic cell , biology , luteinizing hormone , reproductive system , kisspeptin , hormone , leptin , insulin resistance , obesity
Adiponectin is the most important adipokine controlling the food behavior and energy homeostasis. At present, there is much evidence that adiponectin also regulates the functions of the reproductive system, and its targets are hypothalamic neurons responsible for the synthesis and secretion of gonadoliberin, the pituitary gonadotrophs producing the luteinizing hormone, and the gonads. In the target tissues, which are blocks of the hypothalamic-pituitary-gonadal axis, all the main components of adiponectin-regulated signaling system, including adiponectin and both types of adiponectin receptors, are detected. The impairments in the adiponectin signaling pathways lead to the development of reproductive dysfunctions, as a result of which this pathways in the future can become one of the most important targets of therapy of diseases of the male and female reproductive systems. In the review, the current state of the problem of the participation of adiponectin in the functioning of the hypothalamic-pituitary-gonadal axis, and the relationship between the functional status of the reproductive system and the activity of the adiponectin system in hypothalamic neurons, gonadotrophs and gonads are considered.