Open AccessThe polymorphism of IL18RAP and IL18R1 genes associated with risks of the development of myocardial infarction in patients with stable coronary artery disease
Author(s) -
А. В. Понасенко,
А. В. Цепокина,
M. V. Khutornaya,
В. А. Долгих,
I. Yu. Malshev,
О. Л. Барбараш
Publication year - 2018
Publication title -
translâcionnaâ medicina
Language(s) - English
Resource type - Journals
eISSN - 2410-5155
pISSN - 2311-4495
DOI - 10.18705/2311-4495-2018-5-4-12-22
Subject(s) - myocardial infarction , medicine , polymorphism (computer science) , coronary artery disease , pathogenesis , cardiology , disease , interleukin 18 , coronary heart disease , infarction , gene , genotype , genetics , biology , cytokine
Objective: to assess the probability of pathogenic effects OF Il-18 (IL18, IL18R1 and IL18RAP) gene polymorphism on the risk of myocardial infarction in patients with stable coronary heart disease. Materials and methods : the present study was performed with the inclusion of 260 patients with stable coronary heart disease (CHD), residents of the industrial region of Western Siberia. Molecular genetic testing was performed on nine polymorphic sites of il18, IL18R1, IL18RAP genes. Results: associations of polymorphic sites rs13015714 IL18R1 and rs917997 IL18RAP with risks of myocardial infarction were Determined (OR =1.95 (95% CI =1.06-3.58), p =0.029 and OR =2.01 (95% CI =1.11-3.64), p=0.018). Conclusion: to confirm the role of polymorphism IL18, IL18R1, IL18RAP in the pathogenesis of atherosclerosis, prospective monitoring of this group of patients is necessary to identify cases of manifestation of clinical signs in persons with adverse prognosis.