Open AccessMechanisms of beta-blockers antihypertensive action
Author(s) -
Э. В. Кулешова,
N. V. Kuzmenko,
М. Г. Плисс,
В. А. Цырлин
Publication year - 2021
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2021-27-3-291-299
Subject(s) - blockade , adrenergic receptor , pharmacology , adrenergic , vascular tone , receptor , beta (programming language) , blood pressure , adrenergic beta antagonists , medicine , hyperpolarization (physics) , endocrinology , chemistry , vasodilation , organic chemistry , nuclear magnetic resonance spectroscopy , computer science , propranolol , programming language
This article presents an analysis of data on the mechanisms of antihypertensive effect of β-adrenergic receptor blockers. The article describes the effectiveness of cardiotropic action of drugs to reduce high blood pressure (BP) with short-term and long-term action of compounds, the effect of blockers on the activity of plasma renin. The inuence of β-blockers on the central mechanisms of blood circulation regulation is considered. Information on the effect of β-blockers on myogenic mechanisms of vascular tone regulation is presented. The possibilities of blockade of β-adrenergic receptors of endothelium-dependent hyperpolarization of smooth muscles of resistive arteries, violation of the NO-cGMP pathway and blockade of Ca 2+ channel currents as factors providing expansion of resistive vessels and reduction of high BP are analyzed.