Open AccessCurrent knowledge in hypertension genetics: mosaic theory, candidate genes and genome-wide association studies
Author(s) -
А. Конради
Publication year - 2020
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2020-26-5-490-500
Subject(s) - heredity , candidate gene , genetic association , genome wide association study , genetics , essential hypertension , biology , genome , human genetics , mosaic , gene , computational biology , bioinformatics , evolutionary biology , blood pressure , genotype , single nucleotide polymorphism , geography , archaeology , endocrinology
The article reviews monogenic forms of hypertension, data on the role of heredity of essential hypertension and candidate genes, as well as genome-wide association studies. Modern approach for the role of genetics is driven by implementation of new technologies and their productivity. High performance speed of new technologies like genome-wide association studies provide data for better knowledge of genetic markers of hypertension. The major goal nowadays for research is to reveal molecular pathways of blood pressure regulation, which can help to move from populational to individual level of understanding of pathogenesis and treatment targets.