Open AccessLipids in preeclampsia: pathogenic parallels to atherosclerosis
Author(s) -
В. И. Щербаков,
Yа. V. Polonskaya,
Е. В. Каштанова,
А В Ширинская
Publication year - 2020
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2020-26-2-163-169
Subject(s) - pathogenesis , preeclampsia , disease , etiology , endothelial dysfunction , inflammation , medicine , insulin resistance , bioinformatics , oxidative stress , pregnancy , immunology , immune system , diabetes mellitus , lipid metabolism , biology , endocrinology , genetics
Preeclampsia (PE) is one of the most common and serious complications of pregnancy. In women with a history of PE the risk of cardiovascular disease is increased, and atherosclerosis can be induced even during fetal development. The exact mechanisms by which PE increases future cardiovascular risk are unknown, although multiple similarities between mechanisms responsible for cardiovascular disease and PE are reported. Risk factors for PE, such as obesity, insulin resistance, thrombophilia, changes in the lipid spectrum are similar to those for atherosclerosis, which allows us to compare these two conditions to clarify the specifics and is important for understanding the pathogenesis of both pathologies. PE, as well as atherosclerosis, manifests as endothelial dysfunction, abnormal immune function, oxidative stress, activation of inflammation, changes in lipid metabolism. Recent studies have provided a broader understanding of the problem, although there are still many open questions. The etiology and pathogenesis of these diseases, their possible relationship are not fully understood. The article provides a summary of possible common mechanisms of PE and atherosclerosis.