Open AccessThe junctional adhesion molecule-А (JAM-A) and pathogenetic mechanisms of essential hypertension
Author(s) -
Б. И. Кузник,
С. О. Давыдов,
А. В. Степанов,
Екатерина Сергеевна Гусева,
Y. N. Smolyakov,
Ilya Fine
Publication year - 2018
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2018-24-3-293-302
Subject(s) - essential hypertension , pathogenesis , medicine , hemodynamics , blood pressure , estrogen , endocrinology , very low density lipoprotein , adhesion , lipoprotein , cholesterol , chemistry , organic chemistry
Recent studies demonstrated an important role of the junctional adhesion molecule-A (JAM-A) in the pathogenesis of essential hypertension. Our studies showed higher content of JAM-A in women with essential hypertension. Also hypertensive women have higher levels of very low–density lipoprotein (VLDL), higher atherogenic index and lower concentrations of estrogen, progesterone and prolactin, indicating an increased risk of atherosclerosis and premature aging. By the laser speckle showed that the hemodynamic indices considerably change in essential hypertension. The levels of JAM-A correlate with blood pressure, lipids and hemodynamic indices, both in healthy subjects and in women with essential hypertension. The data demonstrate the importance of JAM-A in the pathogenesis of essential hypertension.