Open AccessTHE IMPACT OF ANTI B-CELL THERAPY ON ARTERIAL STIFFNESS IN SYSTEMIC SCLERODERMA
Author(s) -
А. Л. Маслянский,
Ekaterina Kolesova,
Илья Николаевич Пенин,
Мария Дмитриевна Чешуина,
С В Лапин,
А. О. Конради
Publication year - 2013
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2013-19-3-212-220
Subject(s) - arterial stiffness , medicine , rituximab , scleroderma (fungus) , stiffness , arterial wall , cardiology , cyclophosphamide , chemotherapy , blood pressure , pathology , lymphoma , structural engineering , engineering , inoculation
Background. Arterial wall stiffness is an independent predictor of cardiovascular mortality in different patient populations. Currently, there are several studies that show an increase of arterial wall stiffness in systemic sclerosis (SSc). The effect of immunosuppressive therapy on vascular wall stiffness in SSc patients is not investigated. The authors of this paper attempted to study the effect of rituximab and cyclophosphamide combination therapy on vascular stiffness in 5 patients with diffuse form of SSc. Design and methods. We assessed arterial stiffness in 5 patients with diffuse form of SSc before and after 6 months after combined immunosuppressive therapy. Conclusion. The parameters of arterial stiffness decreased in all patients with the moderate effect of the therapy.