Open AccessRENAL SYMPATHETIC DENERVATION FOR THE TREATMENT OF RESISTANT HYPERTENSION — SAFETY CONTROL BY ULTRASOUND TECHNIQUE
Author(s) -
T. Ripp,
V. Mordovin,
С. Е. Пекарский,
Т. Р. Рябова,
М. В. Злобина,
Andrey Krylov,
В. А. Лечикаки,
С. В. Попов,
Р. С. Карпов
Publication year - 2013
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2013-19-2-139-147
Subject(s) - medicine , denervation , renal function , renal sympathetic denervation , blood pressure , ultrasound , blood flow , renal blood flow , urology , cardiology , prospective cohort study , resistive index , kidney , radiology , resistant hypertension
Objective. To assess the safety of transcatheter radiofrequency denervation (TRFD) of renal arteries (RA) in patients with resistant hypertension (RH) by ultrasound of the kidneys. Design and methods. We assessed estimated glomerular filtration rate (eGFR) and performed ultrasound examination of the kidneys and RA at 1, 24 and 48 weeks after TRFD in 35 patients (mean age — 52 +- 10 years) with blood pressure (BP) > 160/100 mmHg despite 3 full-dose antihypertensive drugs as a part of the single-center prospective safety/efficacy study (NCT01499810). Results. Office BP decreased by 34,9/18,2 mmHg (p < 0,001/0,001) and -42,7/-21,7 mmHg (p < 0,01/0,01) at 24 and 48 weeks after TRFD, respectively. No significant changes of eGFR and renal blood flow were found, however, the resistive index (RI) decreased significantly in segmental RA: from 0,62 Ѓ} 0,05 initially till 0,58 +-0,06 and 0,59 +- 0,06, respectively, at follow-up points (p = 0,003; p = 0,049 and p =0,063). Conclusions. TRFD of RA has no adverse effect on either renal function or blood flow in the trunk and segmental branches of the RA. On the contrary, the decrease of resistive index in segmental RA after the intervention indicates improvement of renal blood flow.