Open AccessEFFICACY OF CAPTOPRIL, MOXONIDINE AND THEIR COMBINATIONS WITH NIFEDIPINE IN THE NON-THREATENING HYPERTENSION
Author(s) -
В. В. Руксин,
О. В. Гришин,
Марина Михайловна Чирицо,
Александр Николаевич Малахов,
М. В. Онучин
Publication year - 2013
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2013-19-1-59-65
Subject(s) - moxonidine , captopril , nifedipine , medicine , blood pressure , essential hypertension , heart rate , cardiology , anesthesia , calcium , agonist , receptor
Objective. To study several medications and their combinations in non-threatened hypertension worsening captopril, and moxonidine, captopril + nifedipine, captopril + moxonidine. Design and methods. We include326 patients (253 females) aged 45–89 years who referred for the urgent health care due to the non-threatene hypertension worsening. Mean duration of hypertension was 20,6 ± 0,6 years. Special questionnaires were lle in, heart rate, blood pressure by Korotkoff method, and electrocardiogram were registered. Results. Moxonidinwas shown to be more effective in patients with the sympathetic hyperactivity, captopril — in patients withouincreased sympathetic activity. The combination of captopril and nifedipine was associated with the reductioof therapy ef ciency, and the combination of moxonidine and nifedipine — with its increase. Moreover, administration of captopril and nifedipine led to the higher rate of side effects, compared to the combination moxonidine and nifedipin.