Open AccessBAROREFLEX AND ADAPTATION OF VISCERAL SYSTEMS IN RENOVASCULAR HYPERTENSION
Author(s) -
В. А. Цырлин,
Наталия Владимировна Кузьменко,
М. Г. Плисс,
Н. С. Рубанова
Publication year - 2013
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2013-19-1-32-37
Subject(s) - medicine , renal artery , cardiology , denervation , renovascular hypertension , blood pressure , baroreceptor , carotid sinus , anesthesia , kidney , heart rate
Objective. To test the hypothesis, that the arterial baroreceptor re ex plays the key role for the phenomenon of visceral systems adaptation for long-term afferent drive. Design and methods. In Wistar rats the model of the «two kidneys, one clip» vasorenal hypertension was carried out. The sino-aortic denervation was performed in one group — before the left renal artery clipping, in the other group — 8 weeks after the left renal artery clipping. Results. The renal artery clipping led to the increase of blood pressure only in 17 % of animals with intact sino-carotid-aortic mechanoreceptor zones. The absence of hypertension in these animals might be due to the cardiovascular adaptation phenomenon to prolonged afferent action from ischemic kidney. Denervation of mechanoreceptor zones before the clipping of the renal artery contributes to the development of hypertension in 100 %. However, the denervation of sino-carotid and aortic zones performed 8 weeks after the renal artery clipping in rats without hypertension, does not affect blood pressure level. Conclusion. We suggest, that the absence of hypertension after renal artery clipping is due to the adaptation of the circulatory system to a long-term afferentation from the kidney, and the denervation of large vessels mechanoreceptor zones does not alter this process. At the same time, the damage of the arterial baroreceptor re ex before renal artery clipping interferes in the visceral systems adaptation to afferent action and contributes to the arterial hypertension development.