Open AccessApo E gene polymorphism in patients with metabolic syndrome and cognitive disorders
Author(s) -
Ирина Борисовна Зуева,
Anna Ulitina,
Д. Н. Гораб,
М. В. Москаленко,
М. В. Дубина
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-5-421-428
Subject(s) - allele , genetics , polymorphism (computer science) , anxiety , medicine , allele frequency , apolipoprotein e , gene , endocrinology , biology , psychiatry , disease
Objective. Тс determine allelic variants frequencies caused by Apo E polymorphism in patients with metabolic syndrome and cognitive dysfunction (CD). Design and methods. 54 participants had undergone anthropometric measurements, blood examination (glucose, cholesterol and triglycerides), molecular genetic analysis (polymerase chain reaction, restriction fragments length polymorphism) and neuropsychological tests. Results. Allelic variant s4 of Apo E is an unfavourable factor contributing to the development of CD, depression, anxiety disorders. Allelic variant s2 of Apo E is protective factor in relation to the development of depression.