Open AccessSpontaneous baroreflex in patients with resistant hypertension: Changes during salt loading
Author(s) -
I. Emelyanov,
Alexandra Konradi,
Alexei Y. Bagrov
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-4-292-297
Subject(s) - hydrochlorothiazide , blood pressure , medicine , baroreflex , lisinopril , saline , amlodipine , cardiology , heart rate , anesthesia , angiotensin converting enzyme
Objective. To assess spontaneous baroreflex sensitivity (BRS) in patients with resistant hypertension (RH) and changes during acute salt loading according to changes of blood pressure (BP). Design and methods. Thirty four patients with RH were included. Patients were on standard antihypertensive medication: lisinopril 20 mg per day, amlodipine 10 mg per day and hydrochlorothiazide 25 mg per day. Control group consisted of 11 age- and sex-matched healthy subjects. Salt loading test was performed with i.v. saline infusion (100 ml during 1 hour). Beat-to-beat BP was registered by Finometer Pro device and BRS was assessed by slope method. Results. BRS is reduced in RH patients both at baseline and after salt loading. The level of BP elevation during salt loading is related to BRS reduction, and both parameters are related to salt-sensitivity.