Open AccessBlood pressure, lipid levels and apolipoprotein A1 and paraoxonase 1 gene polymorphisms in patients with abdominal obesity
Author(s) -
H. .. An-Hahar,
О. О. Большакова,
O. Belyaeva,
О. А. Беркович,
В. И. Ларионова,
Е. И. Баранова
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-3-255-266
Subject(s) - dyslipidemia , abdominal obesity , blood pressure , apolipoprotein b , paraoxonase , medicine , obesity , endocrinology , polymorphism (computer science) , allele , lipid profile , gene polymorphism , gene , metabolic syndrome , genetics , biology , cholesterol , oxidative stress
Objective. To evaluate G-75A and C+83T polymorphisms of apolipoprotein A1 gene and Q192R polymorphism of paraoxonase 1 gene and their association with blood pressure and lipid levels in patients with abdominal obesity. Design and methods. We examined 222 obese patients (57 males and 165 females), residents of St Petersburg, Russian Federation. Results. High incidence of arterial hypertension (61 %) and dyslipidemia of different types was revealed. The frequency of different alleles of apolipoprotein A1 and paraoxonase 1 genes was analyzed. The results of gene-gene interactions and their associations with blood pressure, obesity and lipids profiles are presented.