Open AccessThe impact of simvastatin vs. atorvastatin on cognitive function in obese hypertensives
Author(s) -
Ирина Борисовна Зуева,
К. И. Ванаева,
Е. Л. Санец
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-3-228-234
Subject(s) - simvastatin , atorvastatin , medicine , cognition , neuropsychology , cardiology , psychiatry
Objective. To assess the influence of simvastatin vs. atorvastatin therapy on cognitive function in obese hypertensive patients. Design and methods. This open clinical trial included 40 patients (mean age 47,7 ± 5,6 years). 20 patients received simvastatin and 20 — atorvastatin. Monotherapy lasted 12 months. At baseline and 12 months later, all participants underwent neuropsychological testing and cognitive evoked potential (P300) to assess cognitive function. Results. 12-month therapy with simvastatin and atorvastatin significantly improved cognitive function (neuropsychological testing and P300) in obese hypertensives.