Open AccessPossible mechanisms of drug-resistance in hypertensive patients with obstructive sleep apnea
Author(s) -
Надежда Звартау,
Yurii Sviryaev,
L. Korostovtseva,
Alexandra Konradi
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-3-184-190
Subject(s) - obstructive sleep apnea , medicine , hypoxia (environmental) , blood pressure , apnea , cardiology , renin–angiotensin system , sleep apnea , resistant hypertension , endothelial dysfunction , sleep (system call) , anesthesia , aldosterone , chemistry , organic chemistry , oxygen , computer science , operating system
The article reviews possible mechanisms responsible for drug resistance in hypertensive patients with obstructive sleep apnea. Data about more profound target organ damage, partly explained by activation of inflammation, endothelial dysfunction due to recurrent hypoxia episodes and by blood pressure pattern in apnea patients are presented. Stimulation of renin-angiotensin-aldosterone system has a negative impact on cardiovascular system and deteriorates sleep apnea severity.