Open AccessAdiposopathy as a key factor in the development of insulin resistance
Author(s) -
Е. И. Красильникова,
Я. В. Благосклонная,
А. А. Быстрова,
Е. И. Баранова,
М. А. Чилашвили,
В. Л. Степанова,
Инна Леонидовна Рюмина,
А. В. Симаненкова
Publication year - 2012
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2012-18-2-164-176
Subject(s) - hyperinsulinemia , insulin resistance , hyperuricemia , dyslipidemia , metabolic syndrome , abdominal obesity , endothelial dysfunction , medicine , hyperhomocysteinemia , endocrinology , insulin , diabetes mellitus , bioinformatics , risk factor , biology , uric acid
The metabolic cardiovascular syndrome (MS) is a common cluster of metabolic abnormalities (abdominal obesity, hypertension, dyslipidemia and carbohydrate metabolism disorders) that are related to insulin resistance and hyperinsulinemia and are associated with accelerated atherogenesis. Insulin excess is known to promote the development of the whole metabolic cascade. Recently it has been shown that the inflammatory and hemostatic abnormalities, immunological disorders, endothelial dysfunction, hyperhomocysteinemia and hyperuricemia are also important features of MS. Despite the numerous studies of MS its underlying cause is still not established. The dysfunction of visceral adipocytes (adiposopathy) might be genetically determined, and is considered nowadays as the main factor contributing to the development of the MS. Understanding the underlying mechanisms is of particular interest for prevention and target therapy of all the components of MS.