Open AccessDifferential therapeutic approach to hypertensive urgencies
Author(s) -
В. В. Руксин,
О. В. Гришин
Publication year - 2010
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2010-16-3-292-298
Subject(s) - moxonidine , nifedipine , captopril , medicine , clonidine , blood pressure , sympathoadrenal system , guideline , sympathetic activity , antihypertensive drug , anesthesia , cardiology , heart rate , catecholamine , receptor , pathology , calcium , agonist
Design and methods. Effi cacy and safety of several antihypertensive medications were evaluated in 473 cases of nonthreatening hypertensive crisis. Blood pressure (BP) was measured by (Korotkov) method, hemodynamic parameters were evaluated by reographic investigation, and heart rhythm variability was recorded according to the guideline of International Society of Electrophysiology. Results. It was shown that antihypertensive therapy decreasing sympathoadrenal activity are preferable in emergency. In this situation clonidine and moxonidine were the most effective. Captopril was active if high diastolic blood pressure was registered. Nifedipine effi cacy decreased in patients with high sympathoadrenal activity and high increase of BP. Conclusion. Our results showed that the most effective and safe medication in case of the non-threatening hypertensive crisis was moxonidine