Open AccessMultimodal brain magnetic resonance imaging and perfusion computer assisted tomography scanning in evaluation of cerebroprotective efficacy of antihypertensive therapy
Author(s) -
Е. В. Федоренко,
HJ Wittsack,
А. М. Русина,
Н. Л. Афанасьева,
В. М. Гуляев,
Т. А. Шелковникова,
В. Ю. Усов,
V. Mordovin,
Р. С. Карпов
Publication year - 2009
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2009-15-3-280-284
Subject(s) - magnetic resonance imaging , medicine , perfusion , blood pressure , cerebral blood flow , blood flow , perfusion scanning , cerebral perfusion pressure , basal (medicine) , nuclear medicine , radiology , cardiology , insulin
A multimodal diagnostic study of the brain was carried out in 22 patients with arterial hypertension (mean systolic blood pressure 152,8 ± 7,6 mm Hg, mean diastolic blood pressure 94,6 ± 5,2 mm Hg), without cardiovascular events in anamnesis. Magnetic resonance imaging (MRI) imaging and dynamic contrast-enhanced perfusion X-ray computer assisted tomography scan (DynCT) of the brain were performed at admission and after six months of antihypertensive treatment. Based on the MRI and DynCT visual data the extent of periventricular oedema, dimensions of liquor system and regional cerebral blood flow (as ml/min/100 g tissue) were quantified. The quantitative MRI and DynCT indices were analyzed regarding the decrease of blood pressure. Significant decrease of periventricular oedema and improvement in perfusion of basal ganglii area were observed in patients demonstrated decrease in systolic blood pressure for 12-28 mm Hg. The degree of the blood pressure decrease was not associated with the significant MRI and DynCT data improvement. Hencefore, we conclude that the brain MRI and perfusion DynCT data can be employed for evaluation of cerebroprotective effects of antihypertensive therapy.