Open AccessCPAP-therapy in pharmacologically-treated hypertensive patients with sleep apnea
Author(s) -
Yurii Sviryaev,
Надежда Звартау,
О. P. Rotar,
Lu. S. Korostovtceva,
Alexandra Konradi,
А. Л. Калинкин
Publication year - 2008
Publication title -
arterialʹnaâ gipertenziâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 2411-8524
pISSN - 1607-419X
DOI - 10.18705/1607-419x-2008-14-3-264-269
Subject(s) - medicine , obstructive sleep apnea , blood pressure , ambulatory blood pressure , continuous positive airway pressure , ambulatory , population , sleep apnea , dose , combination therapy , pharmacotherapy , environmental health
Correction of sleep disorders in hypertensive patients with obstructive sleep apnea (OSA) may improve response to treatment and facilitate achievement of target blood pressure (BP). Due to the absence of guidelines and insufficient number of studies in this patient population we decided to conduct a study in order to investigate efficacy of standard antihypertensive treatment in combination with CPAP therapy in hypertensive OSA patients. Population: The study enrolled 60 ambulatory or in-hospital hypertensive patients, which were assigned to 3 treatment groups: OSA patients on standard antihypertensive therapy in combination with CPAP; OSA patients on standard antihypertensive therapy alone; non-OSA patients on standard antihypertensive therapy. Results: After 3 months of treatment, 17 patients in the first group, 12 patients in the second group and 18 patients in the third group achieved target BP. Conclusion: Combination of standard antihypertensive treatment and CPAP in hypertensive OSA patients results in increase of proportion of patients on target and decrease of time to achievement of target BP. Due to effective OSA treatment, addition of CPAP therapy results in higher efficacy of antihypertensive therapy with decrease of the number/ dosages of antihypertensive drugs.